abnormal microglial cell morphology_App<tm1Ck>/App<tm1Ck>,Tg(PDGFB-PSEN1M146L)2Jhd/0

http://metadb.riken.jp/0000136I129BlackSwissC57BL6DBA2SWApptm1CkApptm1CkTgPDGFBPSEN1M146L2Jhd0TgPDGFBPSEN1M146L2JhdApptm1Ck

abnormal microglial cell morphology_App<tm1Ck>/App<tm1Ck>,Tg(PDGFB-PSEN1M146L)2Jhd/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• amyloid beta (A4) precursor protein
  http://metadb.riken.jp/db/mgi_rdf/MGI:88059
• transgene insertion 2, John Hardy
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448598

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• App<tm1Ck>/App<tm1Ck>,Tg(PDGFB-PSEN1M146L)2Jhd/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(PDGFB-PSEN1M146L)2Jhd|App<tm1Ck>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal microglial cell morphology
  http://purl.obolibrary.org/obo/MP_0000136

文献

http://purl.org/net/cito/citesAsAuthority

• Christoph. Köhler, et.al., Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels., Neurobiology of disease, 2005, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/15921918