increased circulating LDL cholesterol level_Ldlr<tm1Her>/Ldlr<tm1Her>,Npc1<m1N>/Npc1<m1N>

http://metadb.riken.jp/0000182I129S7SvEvBrdBALBcLdlrtm1HerLdlrtm1HerNpc1m1NNpc1m1NNpc1m1NLdlrtm1Her

increased circulating LDL cholesterol level_Ldlr<tm1Her>/Ldlr<tm1Her>,Npc1<m1N>/Npc1<m1N>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• low density lipoprotein receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:96765
• Niemann-Pick type C1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1097712

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ldlr<tm1Her>/Ldlr<tm1Her>,Npc1<m1N>/Npc1<m1N>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Npc1<m1N>|Ldlr<tm1Her>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd * BALB/c

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased circulating LDL cholesterol level
  http://purl.obolibrary.org/obo/MP_0000182

文献

http://purl.org/net/cito/citesAsAuthority

• Joyce J. Repa, et.al., Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, 27
  http://rdf.ncbi.nlm.nih.gov/pubmed/18160655
• C. Xie, et.al., Cholesterol is sequestered in the brains of mice with Niemann-Pick type C disease but turnover is increased., Journal of neuropathology and experimental neurology, 2000, 59
  http://rdf.ncbi.nlm.nih.gov/pubmed/11138930