increased circulating LDL cholesterol level_Ldlr<tm1Her>/Ldlr<tm1Her>,Lrp1<tm2Her>/Lrp1<tm2Her>,Tg(Mx1-cre)29-4Her/0

http://metadb.riken.jp/0000182I129S7SvEvBrdC57BL6JSJLLdlrtm1HerLdlrtm1HerLrp1tm2HerLrp1tm2HerTgMx1cre294Her0Lrp1tm2HerLdlrtm1HerTgMx1cre294Her

increased circulating LDL cholesterol level_Ldlr<tm1Her>/Ldlr<tm1Her>,Lrp1<tm2Her>/Lrp1<tm2Her>,Tg(Mx1-cre)29-4Her/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• low density lipoprotein receptor-related protein 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:96828
• low density lipoprotein receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:96765
• transgene insertion 29-4, Joachim Herz
  http://metadb.riken.jp/db/mgi_rdf/MGI:2180898

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ldlr<tm1Her>/Ldlr<tm1Her>,Lrp1<tm2Her>/Lrp1<tm2Her>,Tg(Mx1-cre)29-4Her/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lrp1<tm2Her>|Ldlr<tm1Her>|Tg(Mx1-cre)29-4Her

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd * C57BL/6J * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased circulating LDL cholesterol level
  http://purl.obolibrary.org/obo/MP_0000182

文献

http://purl.org/net/cito/citesAsAuthority

• A. Rohlmann, et.al., Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants., The Journal of clinical investigation, 1998, 101
  http://rdf.ncbi.nlm.nih.gov/pubmed/9449704