increased circulating LDL cholesterol level_Ldlr<tm1Her>/Ldlr<tm1Her>

http://metadb.riken.jp/0000182I129S7SvEvBrdLdlrtm1HerLdlrtm1HerLdlrtm1Her

increased circulating LDL cholesterol level_Ldlr<tm1Her>/Ldlr<tm1Her>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• low density lipoprotein receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:96765

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ldlr<tm1Her>/Ldlr<tm1Her>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ldlr<tm1Her>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased circulating LDL cholesterol level
  http://purl.obolibrary.org/obo/MP_0000182

文献

http://purl.org/net/cito/citesAsAuthority

• Ahmed. Zaid, et.al., Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration., Hepatology (Baltimore, Md.), 2008, 48
  http://rdf.ncbi.nlm.nih.gov/pubmed/18666258
• Christopher. Jones, et.al., Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia., The Journal of biological chemistry, 2003, 278
  http://rdf.ncbi.nlm.nih.gov/pubmed/12746448
• Thomas A. Lagace, et.al., Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice., The Journal of clinical investigation, 2006, 116
  http://rdf.ncbi.nlm.nih.gov/pubmed/17080197