abnormal myocardial fiber morphology_Lep<ob>/Lep<ob>

http://metadb.riken.jp/0000278B6CgLepobJLepobLepobLepob

abnormal myocardial fiber morphology_Lep<ob>/Lep<ob>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• leptin
  http://metadb.riken.jp/db/mgi_rdf/MGI:104663

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lep<ob>/Lep<ob>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lep<ob>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• B6.Cg-Lep<ob>/J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal myocardial fiber morphology
  http://purl.obolibrary.org/obo/MP_0000278

文献

http://purl.org/net/cito/citesAsAuthority

• S-Y. Li, et.al., Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch., Diabetologia, 2006, 49
  http://rdf.ncbi.nlm.nih.gov/pubmed/16612592
• F. Dong, et.al., Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice., The Journal of endocrinology, 2006, 188
  http://rdf.ncbi.nlm.nih.gov/pubmed/16394172
• Lili A. Barouch, et.al., Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice., Circulation, 2003, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/12885755