abnormal atrioventricular cushion morphology_Tg(CAG-cat,-Ptpn11*Q510E)#Krnz/0,Tg(Tek-cre)1Ywa/0

http://metadb.riken.jp/0000297IC57BL6FVBNSJLTgCAGcatPtpn11Q510EKrnz0TgTekcre1Ywa0TgTekcre1YwaTgCAGcatPtpn11Q510EKrnz

abnormal atrioventricular cushion morphology_Tg(CAG-cat,-Ptpn11*Q510E)#Krnz/0,Tg(Tek-cre)1Ywa/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Masashi Yanagisawa
  http://metadb.riken.jp/db/mgi_rdf/MGI:2450309
• transgene insertion, Maike Krenz
  http://metadb.riken.jp/db/mgi_rdf/MGI:5828596

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(CAG-cat,-Ptpn11*Q510E)#Krnz/0,Tg(Tek-cre)1Ywa/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Tek-cre)1Ywa|Tg(CAG-cat,-Ptpn11*Q510E)#Krnz

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6 * FVB/N * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal atrioventricular cushion morphology
  http://purl.obolibrary.org/obo/MP_0000297

文献

http://purl.org/net/cito/citesAsAuthority

• Michelle A. Edwards, et.al., The Q510E mutation in Shp2 perturbs heart valve development by increasing cell migration., Journal of applied physiology (Bethesda, Md. : 1985), 2015, 118
  http://rdf.ncbi.nlm.nih.gov/pubmed/25359717