decreased cell proliferation_Braf<tm1Sva>/Braf<tm1Sva>,Kras<tm1Bbd>/Kras<+>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>,Raf1<tm2Bacc>/Raf1<tm2Bacc>

http://metadb.riken.jp/0000352I129P2OlaHsd129S1Sv129X1SvJBraftm1SvaBraftm1SvaKrastm1BbdKrasPolr2atm1creERT2BbdPolr2atm1creERT2BbdRaf1tm2BaccRaf1tm2BaccKrasKrastm1BbdPolr2atm1creERT2BbdRaf1tm2BaccBraftm1Sva

decreased cell proliferation_Braf<tm1Sva>/Braf<tm1Sva>,Kras<tm1Bbd>/Kras<+>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>,Raf1<tm2Bacc>/Raf1<tm2Bacc>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Braf transforming gene
  http://metadb.riken.jp/db/mgi_rdf/MGI:88190
• v-raf-leukemia viral oncogene 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97847
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• polymerase (RNA) II (DNA directed) polypeptide A
  http://metadb.riken.jp/db/mgi_rdf/MGI:98086

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Braf<tm1Sva>/Braf<tm1Sva>,Kras<tm1Bbd>/Kras<+>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>,Raf1<tm2Bacc>/Raf1<tm2Bacc>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kras<+>|Kras<tm1Bbd>|Polr2a<tm1(cre/ERT2)Bbd>|Raf1<tm2Bacc>|Braf<tm1Sva>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased cell proliferation
  http://purl.obolibrary.org/obo/MP_0000352

文献

http://purl.org/net/cito/citesAsAuthority

• Rafael B. Blasco, et.al., c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma., Cancer cell, 2011, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/21514245