abnormal urinary bladder urothelium morphology_Ctnnb1<tm1Mmt>/Ctnnb1<tm1Mmt>,Tg(Upk2-cre)6Xrw/0

http://metadb.riken.jp/0000540I129X1SvJFVBNCtnnb1tm1MmtCtnnb1tm1MmtTgUpk2cre6Xrw0TgUpk2cre6XrwCtnnb1tm1Mmt

abnormal urinary bladder urothelium morphology_Ctnnb1<tm1Mmt>/Ctnnb1<tm1Mmt>,Tg(Upk2-cre)6Xrw/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• catenin (cadherin associated protein), beta 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88276
• transgene insertion 6, Xue-Ru Wu
  http://metadb.riken.jp/db/mgi_rdf/MGI:3583892

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ctnnb1<tm1Mmt>/Ctnnb1<tm1Mmt>,Tg(Upk2-cre)6Xrw/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Upk2-cre)6Xrw|Ctnnb1<tm1Mmt>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129X1/SvJ * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal urinary bladder urothelium morphology
  http://purl.obolibrary.org/obo/MP_0000540

文献

http://purl.org/net/cito/citesAsAuthority

• I. Ahmad, et.al., β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation., Oncogene, 2011, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/20818428
• I. Ahmad, et.al., Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis., Cell death & disease, 2011, 2
  http://rdf.ncbi.nlm.nih.gov/pubmed/21368895