abnormal hepatocyte morphology_Krt8<tm1Rgo>/Krt8<tm1Rgo>

http://metadb.riken.jp/0000607I129S2SvPasC57BL6FVBNKrt8tm1RgoKrt8tm1RgoKrt8tm1Rgo

abnormal hepatocyte morphology_Krt8<tm1Rgo>/Krt8<tm1Rgo>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• keratin 8
  http://metadb.riken.jp/db/mgi_rdf/MGI:96705

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Krt8<tm1Rgo>/Krt8<tm1Rgo>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Krt8<tm1Rgo>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S2/SvPas * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal hepatocyte morphology
  http://purl.obolibrary.org/obo/MP_0000607

文献

http://purl.org/net/cito/citesAsAuthority

• S. Gilbert, et.al., Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation., The Journal of cell biology, 2001, 154
  http://rdf.ncbi.nlm.nih.gov/pubmed/11514590
• Guo-Zhong. Tao, et.al., Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury., Journal of cell science, 2003, 116
  http://rdf.ncbi.nlm.nih.gov/pubmed/14576356
• A. Loranger, et.al., Simple epithelium keratins are required for maintenance of hepatocyte integrity., The American journal of pathology, 1997, 151
  http://rdf.ncbi.nlm.nih.gov/pubmed/9403718
• D M. Toivola, et.al., Protein phosphatase inhibition in normal and keratin 8/18 assembly-incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity., Hepatology (Baltimore, Md.), 1998, 28
  http://rdf.ncbi.nlm.nih.gov/pubmed/9657104
• D M. Toivola, et.al., Disturbances in hepatic cell-cycle regulation in mice with assembly-deficient keratins 8/18., Hepatology (Baltimore, Md.), 2001, 34
  http://rdf.ncbi.nlm.nih.gov/pubmed/11732007
• C. Caulin, et.al., Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis., The Journal of cell biology, 2000, 149
  http://rdf.ncbi.nlm.nih.gov/pubmed/10747083