prostate gland hyperplasia_Gt(ROSA)26Sor<tm2(H1/tetO-RNAi:Pdpk1)Mrl>/Gt(ROSA)26Sor<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Pbsn-cre)4Prb/0

http://metadb.riken.jp/0000659I129S4SvJaeC57BL6DBA2GtROSA26Sortm2H1tetORNAiPdpk1MrlGtROSA26SorPtentm1HwuPtentm1HwuTgPbsncre4Prb0Ptentm1HwuTgPbsncre4PrbGtROSA26SorGtROSA26Sortm2H1tetORNAiPdpk1Mrl

prostate gland hyperplasia_Gt(ROSA)26Sor<tm2(H1/tetO-RNAi:Pdpk1)Mrl>/Gt(ROSA)26Sor<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Pbsn-cre)4Prb/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 4, Pradip Roy-Burman
  http://metadb.riken.jp/db/mgi_rdf/MGI:2388169
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm2(H1/tetO-RNAi:Pdpk1)Mrl>/Gt(ROSA)26Sor<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Pbsn-cre)4Prb/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pten<tm1Hwu>|Tg(Pbsn-cre)4Prb|Gt(ROSA)26Sor<+>|Gt(ROSA)26Sor<tm2(H1/tetO-RNAi:Pdpk1)Mrl>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• prostate gland hyperplasia
  http://purl.obolibrary.org/obo/MP_0000659

文献

http://purl.org/net/cito/citesAsAuthority

• Katharine. Ellwood-Yen, et.al., PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models., Cancer research, 2011, 71
  http://rdf.ncbi.nlm.nih.gov/pubmed/21493594