enlarged spleen_Notch1<tm2Rko>/Notch1<tm2Rko>,Notch2<tm1Rko>/Notch2<tm1Rko>,Notch3<Gt(PST033)Byg>/Notch3<Gt(PST033)Byg>,Tg(Mx1-cre)1Cgn/0

http://metadb.riken.jp/0000691I129P2OlaHsd129X1SvJC57BL6CBANotch1tm2RkoNotch1tm2RkoNotch2tm1RkoNotch2tm1RkoNotch3GtPST033BygNotch3GtPST033BygTgMx1cre1Cgn0TgMx1cre1CgnNotch3GtPST033BygNotch2tm1RkoNotch1tm2Rko

enlarged spleen_Notch1<tm2Rko>/Notch1<tm2Rko>,Notch2<tm1Rko>/Notch2<tm1Rko>,Notch3<Gt(PST033)Byg>/Notch3<Gt(PST033)Byg>,Tg(Mx1-cre)1Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• notch 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:97364
• notch 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97363
• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072
• notch 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:99460

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Notch1<tm2Rko>/Notch1<tm2Rko>,Notch2<tm1Rko>/Notch2<tm1Rko>,Notch3<Gt(PST033)Byg>/Notch3<Gt(PST033)Byg>,Tg(Mx1-cre)1Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Mx1-cre)1Cgn|Notch3<Gt(PST033)Byg>|Notch2<tm1Rko>|Notch1<tm2Rko>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• enlarged spleen
  http://purl.obolibrary.org/obo/MP_0000691

文献

http://purl.org/net/cito/citesAsAuthority

• Apostolos. Klinakis, et.al., A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia., Nature, 2011, 473
  http://rdf.ncbi.nlm.nih.gov/pubmed/21562564