decreased thymocyte number_Tcra<tm1Mom>/Tcra/Tcrd<tm1.1(Tcra)Rsky>,H2<d>/H2<d>,Ptcra<tm1Vbo>/Ptcra<tm1Vbo>,Tg(Tcrb)93Vbo/?

http://metadb.riken.jp/0000715I129P2OlaHsdC57BL6JDBA2JTcratm1MomTcraTcrdtm11TcraRskyH2dH2dPtcratm1VboPtcratm1VboTgTcrb93VboTcraTcrdtm11TcraRskyTcraPtcratm1VboTcrdTcratm1MomTgTcrb93VboH2d

decreased thymocyte number_Tcra<tm1Mom>/Tcra/Tcrd<tm1.1(Tcra)Rsky>,H2<d>/H2<d>,Ptcra<tm1Vbo>/Ptcra<tm1Vbo>,Tg(Tcrb)93Vbo/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• T cell receptor alpha chain
  http://metadb.riken.jp/db/mgi_rdf/MGI:98553
• transgene insertion 93, Harald von Boehmer
  http://metadb.riken.jp/db/mgi_rdf/MGI:3056728
• pre T cell antigen receptor alpha
  http://metadb.riken.jp/db/mgi_rdf/MGI:104857
• histocompatibility-2, MHC
  http://metadb.riken.jp/db/mgi_rdf/MGI:95894
• T cell receptor delta chain
  http://metadb.riken.jp/db/mgi_rdf/MGI:98611

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tcra<tm1Mom>/Tcra/Tcrd<tm1.1(Tcra)Rsky>,H2<d>/H2<d>,Ptcra<tm1Vbo>/Ptcra<tm1Vbo>,Tg(Tcrb)93Vbo/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tcra/Tcrd<tm1.1(Tcra)Rsky>|Tcra<+>|Ptcra<tm1Vbo>|Tcrd<+>|Tcra<tm1Mom>|Tg(Tcrb)93Vbo|H2<d>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased thymocyte number
  http://purl.obolibrary.org/obo/MP_0000715

文献

http://purl.org/net/cito/citesAsAuthority

• Andrew L. Croxford, et.al., MHC-restricted T cell receptor signaling is required for alpha beta TCR replacement of the pre T cell receptor., European journal of immunology, 2008, 38
  http://rdf.ncbi.nlm.nih.gov/pubmed/18203137