abnormal cerebral cortex morphology_Psen1<tm2Shn>/Psen1<tm4.1Shn>,Psen2<tm1Haa>/Psen2<tm1Haa>,Tg(Camk2a-cre)1Shn/0

http://metadb.riken.jp/0000788I129129S4SvJaeC57BL6C57BL6JCBAPsen1tm2ShnPsen1tm41ShnPsen2tm1HaaPsen2tm1HaaTgCamk2acre1Shn0Psen1tm41ShnPsen1tm2ShnPsen2tm1HaaTgCamk2acre1Shn

abnormal cerebral cortex morphology_Psen1<tm2Shn>/Psen1<tm4.1Shn>,Psen2<tm1Haa>/Psen2<tm1Haa>,Tg(Camk2a-cre)1Shn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• presenilin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1202717
• presenilin 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:109284
• transgene insertion 1, Jie Shen
  http://metadb.riken.jp/db/mgi_rdf/MGI:3777952

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Psen1<tm2Shn>/Psen1<tm4.1Shn>,Psen2<tm1Haa>/Psen2<tm1Haa>,Tg(Camk2a-cre)1Shn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Psen1<tm4.1Shn>|Psen1<tm2Shn>|Psen2<tm1Haa>|Tg(Camk2a-cre)1Shn

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6J * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal cerebral cortex morphology
  http://purl.obolibrary.org/obo/MP_0000788

文献

http://purl.org/net/cito/citesAsAuthority

• Dan. Xia, et.al., Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease., Neuron, 2015, 85
  http://rdf.ncbi.nlm.nih.gov/pubmed/25741723