demyelination_S1pr1<tm1Jch>/S1pr1<tm1Jch>,Tg(GFAP-cre)25Mes/?

http://metadb.riken.jp/0000921IC57BL6JFVBNS1pr1tm1JchS1pr1tm1JchTgGFAPcre25MesS1pr1tm1JchTgGFAPcre25Mes

demyelination_S1pr1<tm1Jch>/S1pr1<tm1Jch>,Tg(GFAP-cre)25Mes/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• sphingosine-1-phosphate receptor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1096355
• transgene insertion 25, Albee Messing
  http://metadb.riken.jp/db/mgi_rdf/MGI:2179047

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• S1pr1<tm1Jch>/S1pr1<tm1Jch>,Tg(GFAP-cre)25Mes/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• S1pr1<tm1Jch>|Tg(GFAP-cre)25Mes

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6J * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• demyelination
  http://purl.obolibrary.org/obo/MP_0000921

文献

http://purl.org/net/cito/citesAsAuthority

• Ji Woong. Choi, et.al., FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21177428