decreased motor neuron number_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN1*A2G)2023Ahmb/0,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>

http://metadb.riken.jp/0000939I129P2OlaHsdFVBNSmn1tm1MsdSmn1tm1MsdTgSMN1A2G2023Ahmb0Grm7TgSMN289AhmbGrm7TgSMN289AhmbSmn1tm1MsdTgSMN1A2G2023AhmbGrm7TgSMN289Ahmb

decreased motor neuron number_Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN1*A2G)2023Ahmb/0,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 2023, Arthur H M Burghes
  http://metadb.riken.jp/db/mgi_rdf/MGI:3033247
• survival motor neuron 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:109257
• glutamate receptor, metabotropic 7
  http://metadb.riken.jp/db/mgi_rdf/MGI:1351344

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Smn1<tm1Msd>/Smn1<tm1Msd>,Tg(SMN1*A2G)2023Ahmb/0,Grm7<Tg(SMN2)89Ahmb>/Grm7<Tg(SMN2)89Ahmb>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Smn1<tm1Msd>|Tg(SMN1*A2G)2023Ahmb|Grm7<Tg(SMN2)89Ahmb>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased motor neuron number
  http://purl.obolibrary.org/obo/MP_0000939

文献

http://purl.org/net/cito/citesAsAuthority

• Tatiana O. Gavrilina, et.al., Neuronal SMN expression corrects spinal muscular atrophy in severe SMA mice while muscle-specific SMN expression has no phenotypic effect., Human molecular genetics, 2008, 17
  http://rdf.ncbi.nlm.nih.gov/pubmed/18178576