abnormal cranial ganglia morphology_Gt(ROSA)26Sor<tm1Sor>/Gt(ROSA)26Sor<+>,Hhat<Tg(TFAP2A-cre)1Will>/Hhat<Tg(TFAP2A-cre)1Will>,Tg(Wnt1-cre)11Rth/0

http://metadb.riken.jp/0001081I129S1Sv129S4SvJaeSor129X1SvJC57BL6CBAGtROSA26Sortm1SorGtROSA26SorHhatTgTFAP2Acre1WillHhatTgTFAP2Acre1WillTgWnt1cre11Rth0TgWnt1cre11RthHhatTgTFAP2Acre1WillGtROSA26SorGtROSA26Sortm1Sor

abnormal cranial ganglia morphology_Gt(ROSA)26Sor<tm1Sor>/Gt(ROSA)26Sor<+>,Hhat<Tg(TFAP2A-cre)1Will>/Hhat<Tg(TFAP2A-cre)1Will>,Tg(Wnt1-cre)11Rth/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• hedgehog acyltransferase
  http://metadb.riken.jp/db/mgi_rdf/MGI:2444681
• transgene insertion 11, David H Rowitch
  http://metadb.riken.jp/db/mgi_rdf/MGI:2447280
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1Sor>/Gt(ROSA)26Sor<+>,Hhat<Tg(TFAP2A-cre)1Will>/Hhat<Tg(TFAP2A-cre)1Will>,Tg(Wnt1-cre)11Rth/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Wnt1-cre)11Rth|Hhat<Tg(TFAP2A-cre)1Will>|Gt(ROSA)26Sor<+>|Gt(ROSA)26Sor<tm1Sor>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal cranial ganglia morphology
  http://purl.obolibrary.org/obo/MP_0001081

文献

http://purl.org/net/cito/citesAsAuthority

• Jennifer F. Dennis, et.al., Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects., PLoS genetics, 2012, 8
  http://rdf.ncbi.nlm.nih.gov/pubmed/23055936