hyperpigmentation_Cdkn2a<tm2.1Nesh>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<+>,Tg(Tyr-cre/ERT2)13Bos/0

http://metadb.riken.jp/0001188I129P2OlaHsd129S4SvJaeFVBCdkn2atm21NeshCdkn2aKrastm4TyjKrasTrp53tm1BrnTrp53TgTyrcreERT213Bos0Krastm4TyjKrasTrp53tm1BrnTrp53TgTyrcreERT213BosCdkn2aCdkn2atm21Nesh

hyperpigmentation_Cdkn2a<tm2.1Nesh>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<+>,Tg(Tyr-cre/ERT2)13Bos/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 13, Marcus Bosenberg
  http://metadb.riken.jp/db/mgi_rdf/MGI:3641202
• cyclin-dependent kinase inhibitor 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:104738

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn2a<tm2.1Nesh>/Cdkn2a<+>,Kras<tm4Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<+>,Tg(Tyr-cre/ERT2)13Bos/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kras<tm4Tyj>|Kras<+>|Trp53<tm1Brn>|Trp53<+>|Tg(Tyr-cre/ERT2)13Bos|Cdkn2a<+>|Cdkn2a<tm2.1Nesh>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * FVB

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• hyperpigmentation
  http://purl.obolibrary.org/obo/MP_0001188

文献

http://purl.org/net/cito/citesAsAuthority

• K B. Monahan, et.al., Somatic p16(INK4a) loss accelerates melanomagenesis., Oncogene, 2010, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/20697345