increased metastatic potential_Cdh1<tm1Jjon>/Cdh1<tm1Jjon>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

http://metadb.riken.jp/0001272I129P2OlaHsdFVBNCdh1tm1JjonCdh1tm1JjonTrp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0Trp53tm1BrnTgKRT14cre8BrnCdh1tm1Jjon

increased metastatic potential_Cdh1<tm1Jjon>/Cdh1<tm1Jjon>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 8, Anton Berns
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177242
• cadherin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88354

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdh1<tm1Jjon>/Cdh1<tm1Jjon>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brn>|Tg(KRT14-cre)8Brn|Cdh1<tm1Jjon>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased metastatic potential
  http://purl.obolibrary.org/obo/MP_0001272

文献

http://purl.org/net/cito/citesAsAuthority

• Patrick W B. Derksen, et.al., Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis., Cancer cell, 2006, 10
  http://rdf.ncbi.nlm.nih.gov/pubmed/17097565