increased metastatic potential_Amhr2<tm3(cre)Bhr>/Amhr2<+>,Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>

http://metadb.riken.jp/0001272I129S4SvJae129S7SvEvBrd129X1SvJAmhr2tm3creBhrAmhr2Ctnnb1tm1MmtCtnnb1Ptentm1HwuPtentm1HwuCtnnb1Ctnnb1tm1MmtAmhr2Ptentm1HwuAmhr2tm3creBhr

increased metastatic potential_Amhr2<tm3(cre)Bhr>/Amhr2<+>,Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• catenin (cadherin associated protein), beta 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88276
• anti-Mullerian hormone type 2 receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:105062
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Amhr2<tm3(cre)Bhr>/Amhr2<+>,Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ctnnb1<+>|Ctnnb1<tm1Mmt>|Amhr2<+>|Pten<tm1Hwu>|Amhr2<tm3(cre)Bhr>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * 129S7/SvEvBrd * 129X1/SvJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased metastatic potential
  http://purl.obolibrary.org/obo/MP_0001272

文献

http://purl.org/net/cito/citesAsAuthority

• Alexandre. Boyer, et.al., Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis., Carcinogenesis, 2009, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/19237610
• Marie-Noëlle. Laguë, et.al., Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression., Carcinogenesis, 2008, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/18687666