increased metastatic potential_Kras<tm4Tyj>/Kras<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Pbsn-cre)4Prb/0

http://metadb.riken.jp/0001272I129S4SvJaeC57BL6DBA2Krastm4TyjKrasPtentm1HwuPtentm1HwuTgPbsncre4Prb0Ptentm1HwuTgPbsncre4PrbKrasKrastm4Tyj

increased metastatic potential_Kras<tm4Tyj>/Kras<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Pbsn-cre)4Prb/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 4, Pradip Roy-Burman
  http://metadb.riken.jp/db/mgi_rdf/MGI:2388169
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(Pbsn-cre)4Prb/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pten<tm1Hwu>|Tg(Pbsn-cre)4Prb|Kras<+>|Kras<tm4Tyj>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased metastatic potential
  http://purl.obolibrary.org/obo/MP_0001272

文献

http://purl.org/net/cito/citesAsAuthority

• David J. Mulholland, et.al., Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells., Cancer research, 2012, 72
  http://rdf.ncbi.nlm.nih.gov/pubmed/22350410