cataract_Sord<C57BL/Lia>/Sord<C57BL/Lia>,Tg(Cryaa-AKR1B1)648Smch/Tg(Cryaa-AKR1B1)648Smch

http://metadb.riken.jp/0001304IC57BLCBASordC57BLLiaSordC57BLLiaTgCryaaAKR1B1648SmchTgCryaaAKR1B1648SmchSordC57BLLiaTgCryaaAKR1B1648Smch

cataract_Sord<C57BL/Lia>/Sord<C57BL/Lia>,Tg(Cryaa-AKR1B1)648Smch/Tg(Cryaa-AKR1B1)648Smch

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• sorbitol dehydrogenase
  http://metadb.riken.jp/db/mgi_rdf/MGI:98266
• transgene insertion 648, Stephen SM Chung
  http://metadb.riken.jp/db/mgi_rdf/MGI:3783827

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Sord<C57BL/Lia>/Sord<C57BL/Lia>,Tg(Cryaa-AKR1B1)648Smch/Tg(Cryaa-AKR1B1)648Smch

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Sord<C57BL/Lia>|Tg(Cryaa-AKR1B1)648Smch

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• cataracts
  http://purl.obolibrary.org/obo/MP_0001304

文献

http://purl.org/net/cito/citesAsAuthority

• A Y. Lee, et.al., Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens., Proceedings of the National Academy of Sciences of the United States of America, 1995, 92
  http://rdf.ncbi.nlm.nih.gov/pubmed/7708723