extended life span_Mtor<Gt(OST92090)Lex>/Mtor<+>,Pten<tm1Rps>/Pten<+>

http://metadb.riken.jp/0001661I129S1Sv129S5SvEvBrdC57BL6MtorGtOST92090LexMtorPtentm1RpsPtenMtorGtOST92090LexPtentm1RpsPtenMtor

extended life span_Mtor<Gt(OST92090)Lex>/Mtor<+>,Pten<tm1Rps>/Pten<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• mechanistic target of rapamycin (serine/threonine kinase)
  http://metadb.riken.jp/db/mgi_rdf/MGI:1928394
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mtor<Gt(OST92090)Lex>/Mtor<+>,Pten<tm1Rps>/Pten<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mtor<Gt(OST92090)Lex>|Pten<tm1Rps>|Pten<+>|Mtor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S5/SvEvBrd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• extended life span
  http://purl.obolibrary.org/obo/MP_0001661

文献

http://purl.org/net/cito/citesAsAuthority

• David A. Guertin, et.al., mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice., Cancer cell, 2009, 15
  http://rdf.ncbi.nlm.nih.gov/pubmed/19185849