abnormal embryo development_Gt(ROSA)26Sor<tm1(Wnk1)Clhu>/Gt(ROSA)26Sor<+>,Kdr<tm1(cre)Sato>/Kdr<+>,Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>

http://metadb.riken.jp/0001672I129S1Sv129S5SvEvBrdGtROSA26Sortm1Wnk1ClhuGtROSA26SorKdrtm1creSatoKdrWnk1GtOST38262LexWnk1GtOST38262LexKdrtm1creSatoGtROSA26Sortm1Wnk1ClhuWnk1GtOST38262LexGtROSA26SorKdr

abnormal embryo development_Gt(ROSA)26Sor<tm1(Wnk1)Clhu>/Gt(ROSA)26Sor<+>,Kdr<tm1(cre)Sato>/Kdr<+>,Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• WNK lysine deficient protein kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:2442092
• kinase insert domain protein receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:96683

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(Wnk1)Clhu>/Gt(ROSA)26Sor<+>,Kdr<tm1(cre)Sato>/Kdr<+>,Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kdr<tm1(cre)Sato>|Gt(ROSA)26Sor<tm1(Wnk1)Clhu>|Wnk1<Gt(OST38262)Lex>|Gt(ROSA)26Sor<+>|Kdr<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S5/SvEvBrd

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal embryogenesis/ development
  http://purl.obolibrary.org/obo/MP_0001672

文献

http://purl.org/net/cito/citesAsAuthority

• Jian. Xie, et.al., Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice., The American journal of pathology, 2009, 175
  http://rdf.ncbi.nlm.nih.gov/pubmed/19644017