abnormal immune cell physiology_Pcyt1a<tm1Irt>/Pcyt1a<tm1Irt>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

http://metadb.riken.jp/0001819I129C57BL6JPcyt1atm1IrtPcyt1atm1IrtLyz2tm1creIfoLyz2Lyz2Lyz2tm1creIfoPcyt1atm1Irt

abnormal immune cell physiology_Pcyt1a<tm1Irt>/Pcyt1a<tm1Irt>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• lysozyme 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:96897
• phosphate cytidylyltransferase 1, choline, alpha isoform
  http://metadb.riken.jp/db/mgi_rdf/MGI:88557

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pcyt1a<tm1Irt>/Pcyt1a<tm1Irt>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lyz2<+>|Lyz2<tm1(cre)Ifo>|Pcyt1a<tm1Irt>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal immune cell physiology
  http://purl.obolibrary.org/obo/MP_0001819

文献

http://purl.org/net/cito/citesAsAuthority

• D. Zhang, et.al., Macrophages deficient in CTP:Phosphocholine cytidylyltransferase-alpha are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. Molecular genetic evidence that the induction of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response., The Journal of biological chemistry, 2000, 275
  http://rdf.ncbi.nlm.nih.gov/pubmed/10944538