increased activated T cell number_Gt(ROSA)26Sor<tm2(ITK/Syk)Hjum>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0

http://metadb.riken.jp/0001829I129S6SvEvTacC57BL6DBA2GtROSA26Sortm2ITKSykHjumGtROSA26SorTgCd4cre1Cwi0GtROSA26SorGtROSA26Sortm2ITKSykHjumTgCd4cre1Cwi

increased activated T cell number_Gt(ROSA)26Sor<tm2(ITK/Syk)Hjum>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 1, Christopher B Wilson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448688

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm2(ITK/Syk)Hjum>/Gt(ROSA)26Sor<+>,Tg(Cd4-cre)1Cwi/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<+>|Gt(ROSA)26Sor<tm2(ITK/Syk)Hjum>|Tg(Cd4-cre)1Cwi

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased activated T cell number
  http://purl.obolibrary.org/obo/MP_0001829

文献

http://purl.org/net/cito/citesAsAuthority

• Martina P. Bach, et.al., Premature terminal differentiation protects from deregulated lymphocyte activation by ITK-Syk., Journal of immunology (Baltimore, Md. : 1950), 2014, 192
  http://rdf.ncbi.nlm.nih.gov/pubmed/24376268