increased mammary adenocarcinoma incidence_Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul

http://metadb.riken.jp/0001883I129C57BL6FVBNAkt2tm11MbbAkt2tm11MbbTgMMTVErbb2NK1MulTgMMTVErbb2NK1MulAkt2tm11MbbTgMMTVErbb2NK1Mul

increased mammary adenocarcinoma incidence_Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• thymoma viral proto-oncogene 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:104874
• transgene insertion NK1, William Muller
  http://metadb.riken.jp/db/mgi_rdf/MGI:3513809

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Akt2<tm1.1Mbb>/Akt2<tm1.1Mbb>,Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Akt2<tm1.1Mbb>|Tg(MMTV-Erbb2)NK1Mul

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased mammary adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0001883

文献

http://purl.org/net/cito/citesAsAuthority

• Ioanna G. Maroulakou, et.al., Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice., Cancer research, 2007, 67
  http://rdf.ncbi.nlm.nih.gov/pubmed/17210696