increased mammary adenocarcinoma incidence_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)#Tfln/0,Trp53<tm1Brn>/Trp53<+>

http://metadb.riken.jp/0001883I129P2OlaHsd129S6SvEvTacGtROSA26Sortm1Pik3caH1047REganGtROSA26SorTgMMTVcreTfln0Trp53tm1BrnTrp53GtROSA26SorTrp53tm1BrnGtROSA26Sortm1Pik3caH1047REganTrp53TgMMTVcreTfln

increased mammary adenocarcinoma incidence_Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)#Tfln/0,Trp53<tm1Brn>/Trp53<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion, Timothy F Lane
  http://metadb.riken.jp/db/mgi_rdf/MGI:5688658
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/Gt(ROSA)26Sor<+>,Tg(MMTV-cre)#Tfln/0,Trp53<tm1Brn>/Trp53<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<+>|Trp53<tm1Brn>|Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>|Trp53<+>|Tg(MMTV-cre)#Tfln

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S6/SvEvTac

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased mammary adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0001883

文献

http://purl.org/net/cito/citesAsAuthority

• Jessica R. Adams, et.al., Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation., Cancer research, 2011, 71
  http://rdf.ncbi.nlm.nih.gov/pubmed/21324922