increased mammary adenocarcinoma incidence_Brca2<tm1Brn>/Brca2<tm1Brn>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT14-cre)8Brn/0

http://metadb.riken.jp/0001883I129P2OlaHsdFVBNBrca2tm1BrnBrca2tm1BrnTrp53tm1BrnTrp53TgKRT14cre8Brn0Trp53tm1BrnTrp53TgKRT14cre8BrnBrca2tm1Brn

increased mammary adenocarcinoma incidence_Brca2<tm1Brn>/Brca2<tm1Brn>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT14-cre)8Brn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• breast cancer 2, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:109337
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 8, Anton Berns
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177242

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca2<tm1Brn>/Brca2<tm1Brn>,Trp53<tm1Brn>/Trp53<+>,Tg(KRT14-cre)8Brn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brn>|Trp53<+>|Tg(KRT14-cre)8Brn|Brca2<tm1Brn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased mammary adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0001883

文献

http://purl.org/net/cito/citesAsAuthority

• J. Jonkers, et.al., Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer., Nature genetics, 2001, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/11694875