increased mammary adenocarcinoma incidence_Cdh1<tm1Jjon>/Cdh1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

http://metadb.riken.jp/0001883I129P2OlaHsdFVBNCdh1tm1JjonCdh1Trp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0Cdh1tm1JjonTgKRT14cre8BrnCdh1Trp53tm1Brn

increased mammary adenocarcinoma incidence_Cdh1<tm1Jjon>/Cdh1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cadherin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88354
• transgene insertion 8, Anton Berns
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177242
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdh1<tm1Jjon>/Cdh1<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cdh1<tm1Jjon>|Tg(KRT14-cre)8Brn|Cdh1<+>|Trp53<tm1Brn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased mammary adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0001883

文献

http://purl.org/net/cito/citesAsAuthority

• Patrick W B. Derksen, et.al., Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis., Cancer cell, 2006, 10
  http://rdf.ncbi.nlm.nih.gov/pubmed/17097565