mammary gland alveolar hyperplasia_Brca1<tm2Cxd>/Brca1<tm2Cxd>,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53<tm1Brd>/Trp53<+>

http://metadb.riken.jp/0001884I129S6SvEvTac129S7SvEvBrdC57BL6FVBBrca1tm2CxdBrca1tm2CxdTgMMTVcre4Mam0TgMMTVrtTA1Lach0TgtetOEsr1Paf0Trp53tm1BrdTrp53Trp53tm1BrdTgMMTVcre4MamTgtetOEsr1PafTrp53TgMMTVrtTA1LachBrca1tm2Cxd

mammary gland alveolar hyperplasia_Brca1<tm2Cxd>/Brca1<tm2Cxd>,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53<tm1Brd>/Trp53<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 4, Lothar Hennighausen
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176163
• transgene insertion, Priscilla A Furth
  http://metadb.riken.jp/db/mgi_rdf/MGI:5296681
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 1, Lewis A Chodosh
  http://metadb.riken.jp/db/mgi_rdf/MGI:3511873
• breast cancer 1, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:104537

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca1<tm2Cxd>/Brca1<tm2Cxd>,Tg(MMTV-cre)4Mam/0,Tg(MMTV-rtTA)1Lach/0,Tg(tetO-Esr1)#Paf/0,Trp53<tm1Brd>/Trp53<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brd>|Tg(MMTV-cre)4Mam|Tg(tetO-Esr1)#Paf|Trp53<+>|Tg(MMTV-rtTA)1Lach|Brca1<tm2Cxd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• mammary gland alveolar hyperplasia
  http://purl.obolibrary.org/obo/MP_0001884

文献

http://purl.org/net/cito/citesAsAuthority

• L P. Jones, et.al., Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERalpha-negative and ERalpha-positive mammary preneoplasia and cancer., Oncogene, 2008, 27
  http://rdf.ncbi.nlm.nih.gov/pubmed/17653086