increased tumor incidence_Sirt1<tm1.1Cxd>/Sirt1<+>,Trp53<tm1Brd>/Trp53<+>

http://metadb.riken.jp/0002020EI129S6SvEvTac129S7SvEvBrdBlackSwissFVBNorI129S6SvEvTac129S7SvEvBrdC57BL6FVBNSirt1tm11CxdSirt1Trp53tm1BrdTrp53Sirt1tm11CxdSirt1Trp53Trp53tm1Brd

increased tumor incidence_Sirt1<tm1.1Cxd>/Sirt1<+>,Trp53<tm1Brd>/Trp53<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• sirtuin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:2135607
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Sirt1<tm1.1Cxd>/Sirt1<+>,Trp53<tm1Brd>/Trp53<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Sirt1<tm1.1Cxd>|Sirt1<+>|Trp53<+>|Trp53<tm1Brd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd * Black Swiss * FVB/N) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N)

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased tumor incidence
  http://purl.obolibrary.org/obo/MP_0002020

文献

http://purl.org/net/cito/citesAsAuthority

• Rui-Hong. Wang, et.al., Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice., Cancer cell, 2008, 14
  http://rdf.ncbi.nlm.nih.gov/pubmed/18835033