increased tumor incidence_Brca2<tm1Brn>/Brca2<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

http://metadb.riken.jp/0002020I129P2OlaHsdFVBNBrca2tm1BrnBrca2Trp53tm1BrnTrp53tm1BrnTgKRT14cre8Brn0Brca2tm1BrnTgKRT14cre8BrnTrp53tm1BrnBrca2

increased tumor incidence_Brca2<tm1Brn>/Brca2<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 8, Anton Berns
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177242
• breast cancer 2, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:109337
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca2<tm1Brn>/Brca2<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(KRT14-cre)8Brn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Brca2<tm1Brn>|Tg(KRT14-cre)8Brn|Trp53<tm1Brn>|Brca2<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased tumor incidence
  http://purl.obolibrary.org/obo/MP_0002020

文献

http://purl.org/net/cito/citesAsAuthority

• J. Jonkers, et.al., Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer., Nature genetics, 2001, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/11694875