increased sarcoma incidence_Kras<tm5Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>/Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>

http://metadb.riken.jp/0002032I129P2OlaHsd129S4SvJaeC57BL6Krastm5TyjKrasTrp53tm1BrnTrp53tm1BrnGtROSA26Sortm1creERT2TyjGtROSA26Sortm1creERT2TyjKrastm5TyjTrp53tm1BrnKrasGtROSA26Sortm1creERT2Tyj

increased sarcoma incidence_Kras<tm5Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>/Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm5Tyj>/Kras<+>,Trp53<tm1Brn>/Trp53<tm1Brn>,Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>/Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kras<tm5Tyj>|Trp53<tm1Brn>|Kras<+>|Gt(ROSA)26Sor<tm1(cre/ERT2)Tyj>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased sarcoma incidence
  http://purl.obolibrary.org/obo/MP_0002032

文献

http://purl.org/net/cito/citesAsAuthority

• Nathan P. Young, et.al., Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis., Cancer research, 2011, 71
  http://rdf.ncbi.nlm.nih.gov/pubmed/21512139