increased sarcoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Nf1<tm1Par>/Nf1<tm1Par>

http://metadb.riken.jp/0002032I129S1Sv129X1SvJCdkn2atm4RdpCdkn2atm4RdpNf1tm1ParNf1tm1ParNf1tm1ParCdkn2atm4Rdp

increased sarcoma incidence_Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Nf1<tm1Par>/Nf1<tm1Par>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• neurofibromin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97306
• cyclin-dependent kinase inhibitor 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:104738

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn2a<tm4Rdp>/Cdkn2a<tm4Rdp>,Nf1<tm1Par>/Nf1<tm1Par>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Nf1<tm1Par>|Cdkn2a<tm4Rdp>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased sarcoma incidence
  http://purl.obolibrary.org/obo/MP_0002032

文献

http://purl.org/net/cito/citesAsAuthority

• Rebecca D. Dodd, et.al., NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition., Molecular cancer therapeutics, 2013, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/23858101