increased sarcoma incidence_Col1a1<tm1(tetO-EWSR1/ATF1)Yasu>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(EYFP)Cos>,Tg(Mpz-cre)94Imeg/0

http://metadb.riken.jp/0002032I129S4SvJae129X1SvJC57BL6Col1a1tm1tetOEWSR1ATF1YasuCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26Sortm1EYFPCosTgMpzcre94Imeg0GtROSA26Sortm1EYFPCosTgMpzcre94ImegCol1a1tm1tetOEWSR1ATF1YasuGtROSA26Sortm1rtTAM2JaeCol1a1

increased sarcoma incidence_Col1a1<tm1(tetO-EWSR1/ATF1)Yasu>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(EYFP)Cos>,Tg(Mpz-cre)94Imeg/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• collagen, type I, alpha 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88467
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 94, Institute of Molecular Embryology and Genetics
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176595

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Col1a1<tm1(tetO-EWSR1/ATF1)Yasu>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<tm1(EYFP)Cos>,Tg(Mpz-cre)94Imeg/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm1(EYFP)Cos>|Tg(Mpz-cre)94Imeg|Col1a1<tm1(tetO-EWSR1/ATF1)Yasu>|Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>|Col1a1<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased sarcoma incidence
  http://purl.obolibrary.org/obo/MP_0002032

文献

http://purl.org/net/cito/citesAsAuthority

• Kazunari. Yamada, et.al., EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice., The Journal of clinical investigation, 2013, 123
  http://rdf.ncbi.nlm.nih.gov/pubmed/23281395