increased sarcoma incidence_Col1a1<tm1(tetO-EWSR1/ATF1)Yasu>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Wnt1-cre)11Rth/0

http://metadb.riken.jp/0002032I129S4SvJaeC57BL6CBAJDBA2Col1a1tm1tetOEWSR1ATF1YasuCol1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorTgCAGcatlacZ11Miya0TgWnt1cre11Rth0Col1a1GtROSA26Sortm1rtTAM2JaeGtROSA26SorTgWnt1cre11RthTgCAGcatlacZ11MiyaCol1a1tm1tetOEWSR1ATF1Yasu

increased sarcoma incidence_Col1a1<tm1(tetO-EWSR1/ATF1)Yasu>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Wnt1-cre)11Rth/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• collagen, type I, alpha 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88467
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 11, Jun-ichi Miyazaki
  http://metadb.riken.jp/db/mgi_rdf/MGI:3762382
• transgene insertion 11, David H Rowitch
  http://metadb.riken.jp/db/mgi_rdf/MGI:2447280

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Col1a1<tm1(tetO-EWSR1/ATF1)Yasu>/Col1a1<+>,Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>/Gt(ROSA)26Sor<+>,Tg(CAG-cat-lacZ)11Miya/0,Tg(Wnt1-cre)11Rth/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Col1a1<+>|Gt(ROSA)26Sor<tm1(rtTA*M2)Jae>|Gt(ROSA)26Sor<+>|Tg(Wnt1-cre)11Rth|Tg(CAG-cat-lacZ)11Miya|Col1a1<tm1(tetO-EWSR1/ATF1)Yasu>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * CBA/J * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased sarcoma incidence
  http://purl.obolibrary.org/obo/MP_0002032

文献

http://purl.org/net/cito/citesAsAuthority

• Kazunari. Yamada, et.al., EWS/ATF1 expression induces sarcomas from neural crest-derived cells in mice., The Journal of clinical investigation, 2013, 123
  http://rdf.ncbi.nlm.nih.gov/pubmed/23281395