increased carcinoma incidence_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>

http://metadb.riken.jp/0002038I129S6SvEvTac129S7SvEvBrdBrca1tm21CxdBrca1tm21CxdTrp53tm1BrdTrp53Brca1tm21CxdTrp53tm1BrdTrp53

increased carcinoma incidence_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• breast cancer 1, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:104537

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Trp53<tm1Brd>/Trp53<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Brca1<tm2.1Cxd>|Trp53<tm1Brd>|Trp53<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * 129S7/SvEvBrd

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased carcinoma incidence
  http://purl.obolibrary.org/obo/MP_0002038

文献

http://purl.org/net/cito/citesAsAuthority

• Liu. Cao, et.al., Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach., Carcinogenesis, 2007, 28
  http://rdf.ncbi.nlm.nih.gov/pubmed/17363841