increased pituitary adenoma incidence_Cdkn1b<tm1Ako>/Cdkn1b<tm1Ako>,Cdkn2c<tm1Yxi>/Cdkn2c<tm1Yxi>

http://metadb.riken.jp/0002041I129Sv129S1SvC57BL6DBA2Cdkn1btm1AkoCdkn1btm1AkoCdkn2ctm1YxiCdkn2ctm1YxiCdkn2ctm1YxiCdkn1btm1Ako

increased pituitary adenoma incidence_Cdkn1b<tm1Ako>/Cdkn1b<tm1Ako>,Cdkn2c<tm1Yxi>/Cdkn2c<tm1Yxi>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cyclin-dependent kinase inhibitor 1B
  http://metadb.riken.jp/db/mgi_rdf/MGI:104565
• cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
  http://metadb.riken.jp/db/mgi_rdf/MGI:105388

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn1b<tm1Ako>/Cdkn1b<tm1Ako>,Cdkn2c<tm1Yxi>/Cdkn2c<tm1Yxi>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cdkn2c<tm1Yxi>|Cdkn1b<tm1Ako>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * 129S1/Sv * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pituitary adenoma incidence
  http://purl.obolibrary.org/obo/MP_0002041

文献

http://purl.org/net/cito/citesAsAuthority

• D S. Franklin, et.al., CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis., Genes & development, 1998, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/9744866