increased lung adenoma incidence_Kras<tm4Tyj>/Kras<+>,Mapkapk2<tm1.1Yaff>/Mapkapk2<tm1.1Yaff>,Trp53<tm1Brn>/Trp53<tm1Brn>

http://metadb.riken.jp/0002048I129P2OlaHsd129S4SvJaeC57BL6Krastm4TyjKrasMapkapk2tm11YaffMapkapk2tm11YaffTrp53tm1BrnTrp53tm1BrnKrasKrastm4TyjTrp53tm1BrnMapkapk2tm11Yaff

increased lung adenoma incidence_Kras<tm4Tyj>/Kras<+>,Mapkapk2<tm1.1Yaff>/Mapkapk2<tm1.1Yaff>,Trp53<tm1Brn>/Trp53<tm1Brn>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• MAP kinase-activated protein kinase 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:109298

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Mapkapk2<tm1.1Yaff>/Mapkapk2<tm1.1Yaff>,Trp53<tm1Brn>/Trp53<tm1Brn>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kras<+>|Kras<tm4Tyj>|Trp53<tm1Brn>|Mapkapk2<tm1.1Yaff>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased lung adenoma incidence
  http://purl.obolibrary.org/obo/MP_0002048

文献

http://purl.org/net/cito/citesAsAuthority

• Sandra. Morandell, et.al., A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo., Cell reports, 2013, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/24239348