increased lung adenoma incidence_Kras<tm4Tyj>/Kras<+>,Sftpc<tm1(cre/ERT2)Blh>/Sftpc<+>,Trp53<tm5Tyj>/Trp53<+>

http://metadb.riken.jp/0002048I129S4SvJaeSor129S6SvEvTacC57BL6Krastm4TyjKrasSftpctm1creERT2BlhSftpcTrp53tm5TyjTrp53Trp53SftpcKrasSftpctm1creERT2BlhTrp53tm5TyjKrastm4Tyj

increased lung adenoma incidence_Kras<tm4Tyj>/Kras<+>,Sftpc<tm1(cre/ERT2)Blh>/Sftpc<+>,Trp53<tm5Tyj>/Trp53<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• surfactant associated protein C
  http://metadb.riken.jp/db/mgi_rdf/MGI:109517

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Sftpc<tm1(cre/ERT2)Blh>/Sftpc<+>,Trp53<tm5Tyj>/Trp53<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<+>|Sftpc<+>|Kras<+>|Sftpc<tm1(cre/ERT2)Blh>|Trp53<tm5Tyj>|Kras<tm4Tyj>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased lung adenoma incidence
  http://purl.obolibrary.org/obo/MP_0002048

文献

http://purl.org/net/cito/citesAsAuthority

• Xia. Xu, et.al., Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma., Proceedings of the National Academy of Sciences of the United States of America, 2012, 109
  http://rdf.ncbi.nlm.nih.gov/pubmed/22411819