increased lung adenoma incidence_Del(15Krt80-Krt18)1Tmm/+,Igs11<tm1Tmm>/Igs11<+>,Krt1c<tm1Tmm>/Krt1c<+>,Tg(Actb-KRAS*G12V,-luc)#Lche/0

http://metadb.riken.jp/0002048I129S7SvEvBrdC57BL6FVBNDel15Krt80Krt181TmmIgs11tm1TmmIgs11Krt1ctm1TmmKrt1cTgActbKRASG12VlucLche0Del15Krt80Krt181TmmTgActbKRASG12VlucLcheKrt1ctm1TmmIgs11Igs11tm1TmmKrt1c

increased lung adenoma incidence_Del(15Krt80-Krt18)1Tmm/+,Igs11<tm1Tmm>/Igs11<+>,Krt1c<tm1Tmm>/Krt1c<+>,Tg(Actb-KRAS*G12V,-luc)#Lche/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• keratin 1 complex
  http://metadb.riken.jp/db/mgi_rdf/MGI:96697
• deletion, Chr 15, Thomas M Magin 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:4410572
• intergenic site 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:5527246
• transgene insertion, Lukas C Heukamp
  http://metadb.riken.jp/db/mgi_rdf/MGI:5526089

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Del(15Krt80-Krt18)1Tmm/+,Igs11<tm1Tmm>/Igs11<+>,Krt1c<tm1Tmm>/Krt1c<+>,Tg(Actb-KRAS*G12V,-luc)#Lche/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Del(15Krt80-Krt18)1Tmm|Tg(Actb-KRAS*G12V,-luc)#Lche|Krt1c<tm1Tmm>|Igs11<+>|+|Igs11<tm1Tmm>|Krt1c<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased lung adenoma incidence
  http://purl.obolibrary.org/obo/MP_0002048

文献

http://purl.org/net/cito/citesAsAuthority

• Katharina. König, et.al., Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model., PloS one, 2013, 8
  http://rdf.ncbi.nlm.nih.gov/pubmed/23536778