decreased tumor incidence_Apc<tm1Mmt>/Apc<+>,Mmp7<tm1Lmm>/Mmp7<tm1Lmm>,Smad4<tm1Mmt>/Smad4<+>

http://metadb.riken.jp/0002052I129S1Sv129S2SvPas129X1SvJApctm1MmtApcMmp7tm1LmmMmp7tm1LmmSmad4tm1MmtSmad4Smad4tm1MmtApctm1MmtMmp7tm1LmmSmad4Apc

decreased tumor incidence_Apc<tm1Mmt>/Apc<+>,Mmp7<tm1Lmm>/Mmp7<tm1Lmm>,Smad4<tm1Mmt>/Smad4<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• adenomatosis polyposis coli
  http://metadb.riken.jp/db/mgi_rdf/MGI:88039
• SMAD family member 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:894293
• matrix metallopeptidase 7
  http://metadb.riken.jp/db/mgi_rdf/MGI:103189

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Apc<tm1Mmt>/Apc<+>,Mmp7<tm1Lmm>/Mmp7<tm1Lmm>,Smad4<tm1Mmt>/Smad4<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Smad4<tm1Mmt>|Apc<tm1Mmt>|Mmp7<tm1Lmm>|Smad4<+>|Apc<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased tumor incidence
  http://purl.obolibrary.org/obo/MP_0002052

文献

http://purl.org/net/cito/citesAsAuthority

• Takanori. Kitamura, et.al., Matrix metalloproteinase 7 is required for tumor formation, but dispensable for invasion and fibrosis in SMAD4-deficient intestinal adenocarcinomas., Laboratory investigation; a journal of technical methods and pathology, 2009, 89
  http://rdf.ncbi.nlm.nih.gov/pubmed/19002110