decreased tumor incidence_Cdk2<tm1Sgo>/Cdk2<tm1Sgo>,Kras<tm1Bbd>/Kras<+>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>

http://metadb.riken.jp/0002052I129S1Sv129X1SvJCdk2tm1SgoCdk2tm1SgoKrastm1BbdKrasPolr2atm1creERT2BbdPolr2atm1creERT2BbdKrasPolr2atm1creERT2BbdKrastm1BbdCdk2tm1Sgo

decreased tumor incidence_Cdk2<tm1Sgo>/Cdk2<tm1Sgo>,Kras<tm1Bbd>/Kras<+>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• polymerase (RNA) II (DNA directed) polypeptide A
  http://metadb.riken.jp/db/mgi_rdf/MGI:98086
• cyclin-dependent kinase 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:104772
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdk2<tm1Sgo>/Cdk2<tm1Sgo>,Kras<tm1Bbd>/Kras<+>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kras<+>|Polr2a<tm1(cre/ERT2)Bbd>|Kras<tm1Bbd>|Cdk2<tm1Sgo>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased tumor incidence
  http://purl.obolibrary.org/obo/MP_0002052

文献

http://purl.org/net/cito/citesAsAuthority

• Marta. Puyol, et.al., A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma., Cancer cell, 2010, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/20609353