decreased tumor incidence_Pip4k2a<tm1.2Lca>/Pip4k2a<tm1.2Lca>,Pip4k2b<Gt(Betageo)1Lca>/Pip4k2b<+>,Trp53<tm1Tyj>/Trp53<tm1Tyj>

http://metadb.riken.jp/0002052I129SSvEv129S2SvPas129S5SvEvBrdPip4k2atm12LcaPip4k2atm12LcaPip4k2bGtBetageo1LcaPip4k2bTrp53tm1TyjTrp53tm1TyjPip4k2bGtBetageo1LcaPip4k2bPip4k2atm12LcaTrp53tm1Tyj

decreased tumor incidence_Pip4k2a<tm1.2Lca>/Pip4k2a<tm1.2Lca>,Pip4k2b<Gt(Betageo)1Lca>/Pip4k2b<+>,Trp53<tm1Tyj>/Trp53<tm1Tyj>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
  http://metadb.riken.jp/db/mgi_rdf/MGI:1298206
• phosphatidylinositol-5-phosphate 4-kinase, type II, beta
  http://metadb.riken.jp/db/mgi_rdf/MGI:1934234
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pip4k2a<tm1.2Lca>/Pip4k2a<tm1.2Lca>,Pip4k2b<Gt(Betageo)1Lca>/Pip4k2b<+>,Trp53<tm1Tyj>/Trp53<tm1Tyj>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pip4k2b<Gt(Betageo)1Lca>|Pip4k2b<+>|Pip4k2a<tm1.2Lca>|Trp53<tm1Tyj>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S/SvEv * 129S2/SvPas * 129S5/SvEvBrd

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased tumor incidence
  http://purl.obolibrary.org/obo/MP_0002052

文献

http://purl.org/net/cito/citesAsAuthority

• Brooke M. Emerling, et.al., Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors., Cell, 2013, 155
  http://rdf.ncbi.nlm.nih.gov/pubmed/24209622