premature death_Prkar1a<tm1.2Lsk>/Prkar1a<+>,Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Col1a1-cre)1Kry/0

http://metadb.riken.jp/0002083I129129P2OlaHsd129S1Sv129X1SvJFVBNPrkar1atm12LskPrkar1aRb1tm2BrnRb1tm2BrnTrp53tm1BrnTrp53tm1BrnTgCol1a1cre1Kry0TgCol1a1cre1KryTrp53tm1BrnPrkar1atm12LskRb1tm2BrnPrkar1a

premature death_Prkar1a<tm1.2Lsk>/Prkar1a<+>,Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Col1a1-cre)1Kry/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• RB transcriptional corepressor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97874
• transgene insertion 1, Gerard Karsenty
  http://metadb.riken.jp/db/mgi_rdf/MGI:3041865
• protein kinase, cAMP dependent regulatory, type I, alpha
  http://metadb.riken.jp/db/mgi_rdf/MGI:104878
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Prkar1a<tm1.2Lsk>/Prkar1a<+>,Rb1<tm2Brn>/Rb1<tm2Brn>,Trp53<tm1Brn>/Trp53<tm1Brn>,Tg(Col1a1-cre)1Kry/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Col1a1-cre)1Kry|Trp53<tm1Brn>|Prkar1a<tm1.2Lsk>|Rb1<tm2Brn>|Prkar1a<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• premature death
  http://purl.obolibrary.org/obo/MP_0002083

文献

http://purl.org/net/cito/citesAsAuthority

• Yan. Chen, et.al., RANKL blockade prevents and treats aggressive osteosarcomas., Science translational medicine, 2015, 7
  http://rdf.ncbi.nlm.nih.gov/pubmed/26659571