premature death_Kras<tm1Bbd>/Kras<+>,Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>

http://metadb.riken.jp/0002083I129Sv129S1Sv129X1SvJC57BL6JSJLKrastm1BbdKrasMap2k1tm1ChrnMap2k1tm1ChrnMap2k2tm1ChrnMap2k2tm1ChrnMap2k1tm1ChrnKrasKrastm1BbdMap2k2tm1Chrn

premature death_Kras<tm1Bbd>/Kras<+>,Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• mitogen-activated protein kinase kinase 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:1346867
• mitogen-activated protein kinase kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1346866

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm1Bbd>/Kras<+>,Map2k1<tm1Chrn>/Map2k1<tm1Chrn>,Map2k2<tm1Chrn>/Map2k2<tm1Chrn>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Map2k1<tm1Chrn>|Kras<+>|Kras<tm1Bbd>|Map2k2<tm1Chrn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• premature death
  http://purl.obolibrary.org/obo/MP_0002083

文献

http://purl.org/net/cito/citesAsAuthority

• Rafael B. Blasco, et.al., c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma., Cancer cell, 2011, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/21514245