premature death_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,Col1a1<tm1(CAG-EGFR)Char>/Col1a1<tm2(CAG-EGFR*)Char>,Pten<tm1Hwu>/Pten<tm1Hwu>

http://metadb.riken.jp/0002083I129Sv129S4SvJaeC57BL6SJLCdkn2atm1RdpCdkn2atm1RdpCol1a1tm1CAGEGFRCharCol1a1tm2CAGEGFRCharPtentm1HwuPtentm1HwuCol1a1tm1CAGEGFRCharCdkn2atm1RdpPtentm1HwuCol1a1tm2CAGEGFRChar

premature death_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,Col1a1<tm1(CAG-EGFR)Char>/Col1a1<tm2(CAG-EGFR*)Char>,Pten<tm1Hwu>/Pten<tm1Hwu>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• collagen, type I, alpha 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88467
• cyclin-dependent kinase inhibitor 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:104738
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,Col1a1<tm1(CAG-EGFR)Char>/Col1a1<tm2(CAG-EGFR*)Char>,Pten<tm1Hwu>/Pten<tm1Hwu>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Col1a1<tm1(CAG-EGFR)Char>|Cdkn2a<tm1Rdp>|Pten<tm1Hwu>|Col1a1<tm2(CAG-EGFR*)Char>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• premature death
  http://purl.obolibrary.org/obo/MP_0002083

文献

http://purl.org/net/cito/citesAsAuthority

• Haihao. Zhu, et.al., Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106
  http://rdf.ncbi.nlm.nih.gov/pubmed/19196966