premature death_Tg(SOD1*G93A)1Gur/0

http://metadb.riken.jp/0002083IC57BL6SJLTgSOD1G93A1Gur0TgSOD1G93A1Gur

premature death_Tg(SOD1*G93A)1Gur/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Mark E Gurney
  http://metadb.riken.jp/db/mgi_rdf/MGI:2388308

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tg(SOD1*G93A)1Gur/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(SOD1*G93A)1Gur

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• premature death
  http://purl.obolibrary.org/obo/MP_0002083

文献

http://purl.org/net/cito/citesAsAuthority

• Han-Xiang. Deng, et.al., Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria., Proceedings of the National Academy of Sciences of the United States of America, 2006, 103
  http://rdf.ncbi.nlm.nih.gov/pubmed/16636275
• Dairín. Kieran, et.al., Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice., Proceedings of the National Academy of Sciences of the United States of America, 2007, 104
  http://rdf.ncbi.nlm.nih.gov/pubmed/18077368
• Lynsey G. Bilsland, et.al., Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, 20
  http://rdf.ncbi.nlm.nih.gov/pubmed/16571781
• R. Geracitano, et.al., Altered long-term corticostriatal synaptic plasticity in transgenic mice overexpressing human CU/ZN superoxide dismutase (GLY(93)-->ALA) mutation., Neuroscience, 2003, 118
  http://rdf.ncbi.nlm.nih.gov/pubmed/12699776
• Christine M. Wooley, et.al., Gait analysis detects early changes in transgenic SOD1(G93A) mice., Muscle & nerve, 2005, 32
  http://rdf.ncbi.nlm.nih.gov/pubmed/15880561
• Diether. Lambrechts, et.al., VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death., Nature genetics, 2003, 34
  http://rdf.ncbi.nlm.nih.gov/pubmed/12847526