abnormal lipid homeostasis_Lcat<tm1Hgc>/Lcat<tm1Hgc>,Ldlr<tm1Her>/Ldlr<tm1Her>

http://metadb.riken.jp/0002118I129P2OlaHsd129S7SvEvBrdC57BL6DBALcattm1HgcLcattm1HgcLdlrtm1HerLdlrtm1HerLcattm1HgcLdlrtm1Her

abnormal lipid homeostasis_Lcat<tm1Hgc>/Lcat<tm1Hgc>,Ldlr<tm1Her>/Ldlr<tm1Her>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• lecithin cholesterol acyltransferase
  http://metadb.riken.jp/db/mgi_rdf/MGI:96755
• low density lipoprotein receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:96765

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lcat<tm1Hgc>/Lcat<tm1Hgc>,Ldlr<tm1Her>/Ldlr<tm1Her>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lcat<tm1Hgc>|Ldlr<tm1Her>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal lipid homeostasis
  http://purl.obolibrary.org/obo/MP_0002118

文献

http://purl.org/net/cito/citesAsAuthority

• Dominic S. Ng, et.al., Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance., The Journal of biological chemistry, 2004, 279
  http://rdf.ncbi.nlm.nih.gov/pubmed/14668345
• James W. Furbee, et.al., In vivo contribution of LCAT to apolipoprotein B lipoprotein cholesteryl esters in LDL receptor and apolipoprotein E knockout mice., Journal of lipid research, 2002, 43
  http://rdf.ncbi.nlm.nih.gov/pubmed/11893779