decreased brain weight_Phgdh<tm1.2Shfu>/Phgdh<tm1.2Shfu>,Tg(GFAP-cre)25Mes/0

http://metadb.riken.jp/0002175I129P2OlaHsdFVBNPhgdhtm12ShfuPhgdhtm12ShfuTgGFAPcre25Mes0Phgdhtm12ShfuTgGFAPcre25Mes

decreased brain weight_Phgdh<tm1.2Shfu>/Phgdh<tm1.2Shfu>,Tg(GFAP-cre)25Mes/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 25, Albee Messing
  http://metadb.riken.jp/db/mgi_rdf/MGI:2179047
• 3-phosphoglycerate dehydrogenase
  http://metadb.riken.jp/db/mgi_rdf/MGI:1355330

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Phgdh<tm1.2Shfu>/Phgdh<tm1.2Shfu>,Tg(GFAP-cre)25Mes/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Phgdh<tm1.2Shfu>|Tg(GFAP-cre)25Mes

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased brain weight
  http://purl.obolibrary.org/obo/MP_0002175

文献

http://purl.org/net/cito/citesAsAuthority

• Jung Hoon. Yang, et.al., Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain., The Journal of biological chemistry, 2010, 285
  http://rdf.ncbi.nlm.nih.gov/pubmed/20966073